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Search Results for " immune responses "

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阻害剤

天然化合物

133

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T38361	GSK717		IL Receptor , NOD
	GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio...		IL Receptor , NOD
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T21608L	β-Interleukin I (163-171), human Acetate	β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)	Others
	β-Interleukin I (163-171), human Acetateis a peptide that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.		Others
T77761	BMS-502		Others
	BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune respo...		Others
T76699	Sabatolimab	MBG453,NVP-MBG453	Others
	Sabatolimab (MBG453), a humanized IgG4 (S228P) antibody targeting TIM-3, is a potent inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab has potential immunosuppressive activity and selec...		Others
T14513	BBIQ		TLR
	BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 nM for human TLR7.		TLR
T50068	2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide		Others
	2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide is a compound used as a molecular structural unit, a cyclic dipeptide. It induces apoptosis, inhibits cell proliferation and modulates immune responses, an...		Others
T6964	Resiquimod	R848,S28463	HCV Protease , TLR
	Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...		HCV Protease , TLR
T3614	Inosine pranobex	Groprinosin,Isoprinosine,Immunovir,Delimmun	IL Receptor , HIV Protease
	Inosine pranobex (Delimmun) has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production. Through these effects a...		IL Receptor , HIV Protease
T78362	Transglutaminase	TG
	Transglutaminase (TG) is a thiolase that induces intermolecular cross-linking of proteins, by catalysing the formation of isopeptide bonds between the γ-carboxamide group of glutamine residues and the primary ε-amine gro...
T10865	Cot inhibitor-1		TNF , MAPK
	Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a...		TNF , MAPK
T28708	Sch 24937
	Sch 24937 is a potent immunosuppressant on B lymphocyte mediated immune responses.
T27099	CU-3	CU 3,CU3
	CU-3 is a potent and selective inhibitor of diacylglycerol kinase alpha (DGKalpha). CU-3 attenuates cancer cell proliferation and simultaneously enhances immune responses including anti-cancer immunity.
T61110	UC-1V150
	UC-1V150 is a distinct TLR7 agonist, which activates cellular immune responses and exhibits anti-tumor effects. It also serves as a precursor for the synthesis of ISAC molecules, known as immune-stimulating antibody conj...
T25319	Diacetylsplenopentin HCl	Diacetylsplenopentin hydrochloride
	Diacetylsplenopentin HCl is used as a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the imm...
T34026	Phevamine A	PHVA	Others
	Phevamine A (PHVA) is a suppressor of plant immune responses.		Others
T38614	TLR7 agonist 3
	TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.
T40216	PTPN22-IN-1	PTPN22-IN-1
	PTPN22-IN-1, detailed in WO2021007491A1 as compound L-1, is a potent PTPN22 inhibitor, demonstrating an IC50 of 1.4 μM and a Ki of 0.50 μM. This compound achieves over 7-10 fold selectivity against PTPN22 relative to com...
T40452	N-Acetylpsychosine	N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0)
	N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apop...
T73990	Lipid M
	Lipid M (pKa: 6.75) is a potential carrier for mRNA vaccines, offering enhanced immune responses and increased tolerability [1].
T39292	NS2 (114-121), Influenza	NS2 (114-121), Influenza
	NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T l...
T13667	Dusquetide TFA (931395-42-5 free base)	SGX942 TFA,Dusquetide TFA	Others
	Dusquetide TFA is a kind of innate defense regulator (IDR).Dusquetide TFA has been shown to be active in reducing inflammation and increasing clearance of bacterial infections.Dusquetide TFA regulates innate immune respo...		Others
T14035	3M-011		TLR
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibit...		TLR
T69834	Tivumecirnon	FLX475
	Tivumecirnon (FLX475) is a potent antagonist of CCR4, effectively inhibiting regulatory T cells that hinder antitumor immune responses, thereby demonstrating antitumor activity.
T74872	ODN 105870
	ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), selectively inhibits TLR7 and is utilized in the research of inflammatory immune responses [1].
T82142	Hymenistatin I
	Hymenistatin I, a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-Ile-)], exhibits immunosuppressive effects on both humoral and cellular immune responses [1].
T80131	C5a Anaphylatoxin (human)		Complement System
	C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses, including allergic asthma [1] [2].		Complement System
T77775	TP-1454
	TP-1454 is an activator against PKM2 with a biochemically determined AC50 of 10 Nm. It can regulate tumor immune responses by acting on T regulatory cells.
T76241	Trichomide A
	Trichomide A, a natural cyclodepsipeptide, serves as a potent activator of SHP2. This compound exhibits immunosuppressive activity against activated T lymphocyte-mediated immune responses in Con A-activated T cells, high...
T74873	ODN 105871
	ODN 105871, a G-modified inhibitory oligonucleotide (INH-ODN), acts as a selective inhibitor of Toll-like receptor 7 (TLR7). It is utilized in the study of inflammatory immune responses [1].
T27638	Israpafant	Y-24180,Y 24180,Y24180
	Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and co...
T76748	Foralumab
	Foralumab (NI-0401) is a powerful, orally administered humanized monoclonal antibody that specifically targets the CD3 receptor. By modulating immune responses in NSG mice reconstituted with human hematopoietic stem cell...
T79927	Pectate Lyase
	Pectate Lyase, an enzyme secreted by plant pathogens, is essential for pectin degradation and plays a vital role in fungal virulence. Additionally, it triggers plant immune responses, further contributing to its virulenc...
T79488	RNase L-IN-1		DNA/RNA Synthesis
	RNase L-IN-1 (compound 17a) functions as an inhibitor of RNase L (Ribonuclease L), an enzyme responsible for RNA degradation to inhibit viral replication, and plays a crucial role in mediating innate immune responses and...		DNA/RNA Synthesis
T81022	Tegoprubart
	Tegoprubart is a monoclonal antibody targeting CD40 ligand (CD40L), which plays a critical role in costimulation. By inhibiting CD40L, it diminishes both cellular and antibody-mediated immune responses, fostering a more ...
T74268	STING agonist-13
	STING Agonist-13, a stimulator of interferon genes (STING) agonist, enhances cancer immunity through STING-mediated immune activation. It activates STING downstream signaling to promote type I interferon immune responses...
T74584	5-Methylcytidine 5′-triphosphate
	5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate immune responses in human and other mammalian cells when substitu...
T79320	Antitumor agent-114		STING
	Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models, demonstrating potential applications in immunity and cance...		STING
T74706	Vidutolimod
	Vidutolimod (CMP-001), a CpG-A oligodeoxynucleotide and Toll-like receptor 9 (TLR9) agonist, activates plasmacytoid dendritic cells (pDCs) and induces the release of interferon alpha (IFNα), initiating a series of anti-t...
T82858	Bleselumab	ASKP 1240,Anti-Human CD40 Recombinant Antibody
	Bleselumab (ASKP 1240), a human anti-CD40 monoclonal antibody (mAb), exhibits high-affinity binding to CD40 (Kd: 0.24 nM) and hinders immune responses by impeding the CD40-CD40L interaction, thereby preventing organ tran...
T73659	HLF1-11
	HLF1-11, derived from human lactoferrin, serves as a broad-spectrum antimicrobial agent. It not only inhibits human MPO (myeloperoxidase) activity but also influences GM-CSF (granulocyte-macrophage colony-stimulating fac...
T74693	CDN-A
	CDN-A, a cyclic di-nucleotide, serves as a precursor for synthesizing antibody-drug conjugates (ADC) and acts as a potent stimulator of both innate and adaptive immune responses. In humans, these cyclic di-nucleotides, p...
T74585	5-Methylcytidine 5′-triphosphate trisodium
	5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while reducing innate immune responses in human and mammalian cell...
T82793	Caerin 1.1 TFA		Apoptosis
	Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells and induces apoptosis. Additionally, it has the potential to ...		Apoptosis
T80761	XQ2B
	XQ2B is a cGAS inhibitor that impedes protein-DNA interactions and phase separation. It suppresses antiviral immune responses induced by herpes simplex virus 1 (HSV-1) and augments HSV-1 infection in both in vitro and in...
T76156	Sphingomyelin phosphodiesterase
	Sphingomyelin phosphodiesterase, a hydrolase, plays a crucial role in sphingomyelin metabolism by catalyzing the conversion of sphingomyelin into phosphocholine and ceramide. Furthermore, it is instrumental in cellular d...
T78325	Orilanolimab	SYNT001
	Orilanolimab (SYNT001) is a humanized, de-immunized monoclonal antibody that inhibits the FcRn-IgG interaction, thereby disrupting IgG homeostasis and impeding FcRn-mediated adaptive immune responses, as well as related ...
T68383	BIIB028
	BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the prote...
T74905	ODN 2007
	ODN 2007, a class B CpG ODN (oligodeoxynucleotide) and Toll-like receptor (TLR) ligand, serves as an immunomodulator and vaccine adjuvant, promoting enhanced immune responses across mammals, fish, and humans. Its sequenc...

Compounds

GSK717

T38361

Synonym:

Target: IL Receptor, NOD

AMG-47a

T7123

Synonym:

Target: VEGFR, p38 MAPK, JAK, Src

Simeprevir

T4686

Synonym: TMC435,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

β-Interleukin I (163-171), human Acetate

T21608L

Synonym: β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)

Synonym: MBG453,NVP-MBG453

2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide

Target: HCV Protease, TLR

Inosine pranobex

T3614

Synonym: Groprinosin,Isoprinosine,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Diacetylsplenopentin HCl

T25319

Synonym: Diacetylsplenopentin hydrochloride

Synonym: N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0)

NS2 (114-121), Influenza

T39292

Synonym: NS2 (114-121), Influenza

Target:

Dusquetide TFA (931395-42-5 free base)

T13667

Synonym: SGX942 TFA,Dusquetide TFA

C5a Anaphylatoxin (human)

T80131

Synonym:

Target: Complement System

Synonym: Y-24180,Y 24180,Y24180

Target: DNA/RNA Synthesis

5-Methylcytidine 5′-triphosphate

Synonym: ASKP 1240,Anti-Human CD40 Recombinant Antibody

5-Methylcytidine 5′-triphosphate trisodium

Sphingomyelin phosphodiesterase

カタログ番号	製品名	別名	ターゲット
T13502	3-Oxo-5β-cholanoic acid	Dehydrolithocholic acid	ROR
			ROR
TN2088	Platycodin D2		IL Receptor , HBV
	Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci...		IL Receptor , HBV
T0948L	Corticosterone	17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)	Glucocorticoid Receptor , Endogenous Metabolite
	Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres...		Glucocorticoid Receptor , Endogenous Metabolite
T5S0993	Kurarinone		BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameli...		BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
T67710	3-Indoleacrylic acid		Endogenous Metabolite
	3-Indoleacrylic acid is a metabolite of tryptophan produced by Peptostreptococcus species. 3-Indoleacrylic acid has a beneficial effect on intestinal epithelial barrier function and mitigates inflammatory responses by im...		Endogenous Metabolite
T5731	1-Kestose		Others , Endogenous Metabolite , Antibacterial
	1-Kestose shows significant anti-hydroxyl radical potential. 1-Kestose can promote intestinal Lactobacillus number, and influence the microorganisms as well as the intestinal and systemic immune responses.		Others , Endogenous Metabolite , Antibacterial
TN1879	Lucideric acid A	Lucidenic acid A	MMP , p38 MAPK , JNK
	Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation.		MMP , p38 MAPK , JNK
T1614	Hydrocortisone	Cortisol	Glucocorticoid Receptor , Endogenous Metabolite
	Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilizatio...		Glucocorticoid Receptor , Endogenous Metabolite
T4928	L-Kynurenine	(S)-Kynurenine	AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
	L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...		AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
T5S1895	Norisoboldine	Laurelliptine,(+)-Laurelliptine	MAPK , Adenosine Receptor
	1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the abnormal immune responses. 2. Norisobo...		MAPK , Adenosine Receptor
T3386	Kaempferitrin	Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside	cell cycle arrest , Glucokinase , IGF-1R
	Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...		cell cycle arrest , Glucokinase , IGF-1R
TN4804	Platycoside A		Antifection
	Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mi...		Antifection
T38838	QS-21	Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, Q...
TN2181	Sarmentosin		Others
	Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum gluta...		Others

天然物製品

3-Oxo-5β-cholanoic acid

T13502

Synonym: Dehydrolithocholic acid

Target: IL Receptor, HBV

Corticosterone

T0948L

Synonym: 17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)

Target: Glucocorticoid Receptor, Endogenous Metabolite

Kurarinone

T5S0993

Synonym:

Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT

3-Indoleacrylic acid

T67710

Synonym:

Target: Endogenous Metabolite

1-Kestose

T5731

Synonym:

Target: Others, Endogenous Metabolite, Antibacterial

Lucideric acid A

TN1879

Synonym: Lucidenic acid A

Target: MMP, p38 MAPK, JNK

Hydrocortisone

T1614

Synonym: Cortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

L-Kynurenine

T4928

Synonym: (S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Norisoboldine

T5S1895

Synonym: Laurelliptine,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Kaempferitrin

T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside

Target: cell cycle arrest, Glucokinase, IGF-1R

Synonym: Stimulon,QS-21

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-00047	IFN gamma Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experi...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPJ-00387	IL-4R alpha Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions a...
TMPY-02904	TLR4 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans...
TMPJ-00137	APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to relea...
TMPY-02219	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)	H1N1	E. coli
	The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N...
TMPK-01231	CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclamps...
TMPH-02688	Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. Th...
TMPJ-00030	IL-1F10 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 1 Family Member 10 (IL-1F10) is thought to participate in a network of Interleukin 1 cytokine family members to regulate adapted and innate immune responses. IL-1F10 was expressed in fetal skin, spleen ...
TMPK-01230	CLEC2D Protein, Human, Recombinant (hFc & Avi)	Human	HEK293 Cells
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclamps...
TMPK-00565	PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als...
TMPK-00829	Galectin-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Galectin 1(Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has bee...
TMPK-00875	CD96 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cel...
TMPK-00022	Galectin-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Galectin 1 (Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has be...
TMPJ-00440	BTNL4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Butyrophilin-like 4, also known as BTLN4, BTN3A3 (human) and BTN3A2 (rat) is an approximately 65 kDa member of the butyrophilin family that may play a role in immune regulation. BTNL4 shows striking sequence similarity t...
TMPJ-00446	CD32A Protein, Human, Recombinant (R167, His)	Human	HEK293 Cells
	Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (C...
TMPK-01033	PSGL-1/CD162 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als...
TMPK-01539	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPJ-00563	LGALS3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Galectin-3(LGALS3) is also known as Galactose-specific lectin 3, Mac-2 antigen, Carbohydrate-binding protein 35, Laminin-binding protein and Galactoside-binding protein. LGALS3 is highly expressed in early stages of papi...
TMPK-00182	PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated	Human	HEK293 Cells
	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor progr...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPK-01040	NKG2C/CD159c Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role i...
TMPK-01546	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01497	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01449	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)	Human	E. coli
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01500	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-00662	PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated	Cynomolgus,Rhesus	HEK293 Cells
	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor progr...
TMPK-01499	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01331	TSLPR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of t...
TMPK-01513	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01448	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)	Human	E. coli
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-01543	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,...
TMPK-00294	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	LILRA2, also known as ILT1, CD85h, and LIR7, is an approximately 70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA2 consists of a 426 amino acid (aa) extracellul...
TMPK-00295	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	LILRA2, also known as ILT1, CD85h, and LIR7, is an approximately 70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA2 consists of a 426 amino acid (aa) extracellul...
TMPY-03873	CLEC4B2 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Clec4b2, also known as mDCAR1, is a member of the DCIR/DCAR family. Expression of Clec4b2 was strongly tissue dependent. Clec4b2 expression on DCs was restricted to the CD8(+) DC subset in spleen and thymus and on subpop...
TMPK-00535	FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)	Cynomolgus	HEK293 Cells
	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expre...
TMPK-00968	FGL2 Protein, Human, Recombinant (His & Avi, Flag)	Human	HEK293 Cells
	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expre...
TMPH-02879	REG3G Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of th...
TMPJ-00770	Granzyme B/GZMB Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an...
TMPH-03398	VCAM-1 Protein, Rat, Recombinant (His)	Rat	E. coli
	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The ...
TMPK-00985	FGL2 Protein, Rat, Recombinant (His & Avi, Flag), Biotinylated	Rat	HEK293 Cells
	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expre...
TMPK-00813	FGL2 Protein, Mouse, Recombinant (His & Avi, Flag)	Mouse	HEK293 Cells
	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expre...
TMPK-00970	FGL2 Protein, Human, Recombinant (hFc & Flag)	Human	HEK293 Cells
	Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expre...
TMPK-00720	Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	Group B Streptococcus (GBS) causes invasive infections in human newborns. the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory rece...
TMPK-00858	NKG2C/CD159c Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections.The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role in...
TMPK-01262	CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid...
TMPK-01199	NKG2C/CD159c Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections.The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role in...
TMPK-00327	CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases th...
TMPK-01041	FcRH6 /FCRL6 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylo...
TMPH-01067	CEBPD Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the express...
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IFN gamma Protein, Human, Recombinant (His & Avi)

TMPK-00047

Species: Human

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

TMPY-06981

Species: Human

Expression System: E. coli

IL-4R alpha Protein, Mouse, Recombinant (hFc)

TMPJ-00387

Species: Mouse

Expression System: HEK293 Cells

TLR4 Protein, Human, Recombinant (His)

TMPY-02904

Species: Human

Expression System: Baculovirus Insect Cells

APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)

TMPJ-00137

Species: Human

Expression System: HEK293 Cells

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)

TMPY-02219

Species: H1N1

Expression System: E. coli

CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated

TMPK-01231

Species: Human

Expression System: HEK293 Cells

Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc)

TMPH-02688

Species: Mouse

Expression System: E. coli

IL-1F10 Protein, Human, Recombinant

TMPJ-00030

Species: Human

Expression System: E. coli

CLEC2D Protein, Human, Recombinant (hFc & Avi)

TMPK-01230

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)

TMPK-00565

Species: Cynomolgus

Expression System: HEK293 Cells

Galectin-1 Protein, Mouse, Recombinant (hFc)

TMPK-00829

Species: Mouse

Expression System: HEK293 Cells

CD96 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00875

Species: Human

Expression System: HEK293 Cells

Galectin-1 Protein, Human, Recombinant (hFc)

TMPK-00022

Species: Human

Expression System: HEK293 Cells

BTNL4 Protein, Mouse, Recombinant (His)

TMPJ-00440

Species: Mouse

Expression System: HEK293 Cells

CD32A Protein, Human, Recombinant (R167, His)

TMPJ-00446

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (His)

TMPK-01033

Species: Mouse

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

TMPK-01539

Species: Human

Expression System: HEK293 Cells

LGALS3 Protein, Human, Recombinant (His)

TMPJ-00563

Species: Human

Expression System: HEK293 Cells

PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated

TMPK-00182

Species: Human

Expression System: HEK293 Cells

IRF1 Protein, Human, Recombinant (GST & His)

TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

NKG2C/CD159c Protein, Cynomolgus, Recombinant (His)

TMPK-01040

Species: Cynomolgus

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi)

TMPK-01546

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

TMPK-01497

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)

TMPK-01449

Species: Human

Expression System: E. coli

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)

TMPK-01500

Species: Human

Expression System: HEK293 Cells

PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated

TMPK-00662

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)

TMPK-01499

Species: Human

Expression System: HEK293 Cells

TSLPR Protein, Cynomolgus, Recombinant (His)

TMPK-01331

Species: Cynomolgus

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated

TMPK-01513

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)

TMPK-01448

Species: Human

Expression System: E. coli

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi)

TMPK-01543

Species: Human

Expression System: HEK293 Cells

LILRA2/CD85h/ILT1 Protein, Human, Recombinant (His & Avi)

TMPK-00294

Species: Human

Expression System: HEK293 Cells

LILRA2/CD85h/ILT1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00295

Species: Human

Expression System: HEK293 Cells

CLEC4B2 Protein, Rat, Recombinant (His)

TMPY-03873

Species: Rat

Expression System: HEK293 Cells

FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)

TMPK-00535

Species: Cynomolgus

Expression System: HEK293 Cells

FGL2 Protein, Human, Recombinant (His & Avi, Flag)

TMPK-00968

Species: Human

Expression System: HEK293 Cells

REG3G Protein, Mouse, Recombinant (His)

TMPH-02879

Species: Mouse

Expression System: P. pastoris (Yeast)

Granzyme B/GZMB Protein, Mouse, Recombinant (His)

TMPJ-00770

Species: Mouse

Expression System: HEK293 Cells

VCAM-1 Protein, Rat, Recombinant (His)

TMPH-03398

Species: Rat

Expression System: E. coli

FGL2 Protein, Rat, Recombinant (His & Avi, Flag), Biotinylated

TMPK-00985

Species: Rat

Expression System: HEK293 Cells

FGL2 Protein, Mouse, Recombinant (His & Avi, Flag)

TMPK-00813

Species: Mouse

Expression System: HEK293 Cells

FGL2 Protein, Human, Recombinant (hFc & Flag)

TMPK-00970

Species: Human

Expression System: HEK293 Cells

Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

TMPK-00720

Species: Human

Expression System: HEK293 Cells

NKG2C/CD159c Protein, Human, Recombinant (His & Avi)

TMPK-00858

Species: Human

Expression System: HEK293 Cells

CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His)

TMPK-01262

Species: Cynomolgus

Expression System: HEK293 Cells

NKG2C/CD159c Protein, Mouse, Recombinant (hFc)

TMPK-01199

Species: Mouse

Expression System: HEK293 Cells

CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

TMPK-00327

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

FcRH6 /FCRL6 Protein, Human, Recombinant (hFc)

TMPK-01041

Species: Human

Expression System: HEK293 Cells

CEBPD Protein, Human, Recombinant (His & Myc)

TMPH-01067

Species: Human

Expression System: E. coli

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